In this paper, we briefly introduce the definition of SPOC and Flipped Classroom, emphasize the application necessity of the "SPOC based Flipped Classroom" teaching mode in basic medical education, and detailed discuss the basic principles of the "SPOC based Flipped classroom" teaching mode combined with the characteristics of basic medical courses, including the teaching design, course arrangement, evaluation method. Compared with the traditional teaching model, "SPOC-based Flipped Classroom" teaching mode is helpful in cultivating students' interest in learning, initiating students' subjective motive and creation, and improving students' ability to analyze and solve problems. This study could provid ecertain reference for the implementation of Flipped classroom reform in other medical colleges.