The morphological information teaching platform has improved the teaching efficiency in the morphological experimental class, however, the digital specimen library still has the problem of low efficiency. This paper takes the national virtual simulation experiment teaching project "Immunohistochemical detection method for molecular classification of breast cancer tissues" as an example to explore the innovation of morphological experimental teaching. This virtual simulation experiment associates the experimental theory and operation of immunohistochemistry, links the morphology and molecular function of breast cancer, and combines the basic theory of breast cancer with the formulation of clinical treatment plan, to effectively cultivate the clinical practice of medical students, boost students' self-directed learning ability, and ultimately promote the integration of basic and clinical medicine.