The article starts with analyzing the practical significance of accelerating innovation and entrepreneurship education reforms in medical colleges and universities from three aspects of national strategy, talent training and personal development, and then probes into the four bottleneck factors that restrict the development of innovation and entrepreneurship in medical colleges and universities. It puts forward the corresponding solutions from four measures, namely building a curriculum system that is deeply integrated with the major, strengthening the training of "all-rounder" teaching staffs specializing in both theoretical and practical fields, expanding the education coverage, and putting more effort into the construction of practical training bases, so as to explore and build a practical innovation and entrepreneurship education and training system for medical students in line with the laws of medical education and of talent growth.