Objective To improve human resource management system of maternal and child health hospital based on modern hospital management system. Methods The current situation of human resource management system in maternal and child health hospital was analyzed, the existing problems were summarized, and the corresponding system suggestions were put forward. Results The following problems existed in the human resource management of maternal and child health hospital: the shortage of talents was serious, the health function needed to be strengthened, the reform of personnel system was slow, and the salary system was unreasonable. Conclusion Based on the modern hospital management system, combined with the existing problems, we can promote the construction and improvement of human resource management system in maternal and child health hospital by accelerating system reform, innovating talent introduction and training means, paying equal attention to clinical and health care, and building a reasonable salary system.