To analyze the characteristics and influencing factors of hospitalization expenses of COVID-19 patients, we collected 118 patients with new coronavirus pneumonia in the Huangshi Traditional Chinese Medicine Hospital in Hubei Province from February 5 to March 25,2020.The descriptive analysis, stepwise regression analysis, and grey relationalanalysis were used. The total hospitalization cost of high cost group was significantly higher than low cost group, and the drug cost accounted for the highest proportion. F=20.886，P＜0.001，adjusted R2=0.652，And the hospitalization expenses is affected by length of hospitalization、use ventilator、immunomodulator、blood products.