In the face of the Healthy China strategy, promoting ideological and political education and guiding top-notch clinical medical students to participate in scientific research and practice activities as early as possible is of far-reaching and important significance for accelerating scientific and technological innovation, the development of medical colleges and universities and the cultivation of top-notch talents. The Department of Human Anatomy in Nanjing Medical University takes the party building as the guidance, and integrates the concept of "ideological and political education" into the practical study of scientific research innovation of "5 + 3" integrated clinical medical students. It pays more attention to the construction of scientific research spirit at the same time of cultivating their scientific research ability starting from the six aspects of the construction of new entrepreneurial team including “teacher-student team construction, laboratory culture construction, research style construction, practice platform construction, training process standardization construction, and innovation and entrepreneurship team construction”. They have carried out the practice and exploration of the cultivation path of top-notch innovative talents with the main characteristics of "supporting scientific research training education