With the development strategy of Healthy China and the rapid development of mobile Internet technology, it brings new opportunities for the rise of mobile health industry. Based on the online survey of 552 respondents in several provinces and cities nationwide, this paper takes the users of health science APP as the research object. Based on the KAP model and the technology acceptance model, this paper analyzes the basic characteristics, perceived value, cognitive experience of users and whether they have a positive impact on health behaviors. The study finds that people use new media more than traditional media when public crisis happens, but traditional media is more convincing when it comes to the credibility of sources. Users' exposure to health information related to popular science APP will directly affect their health behaviors.