Objective: To explore the optimization of fever clinic management mode in epidemic period in COVID-19 and the effect after optimization. Methods: 1950 cases (from January 2020 to March 2020) who visited the fever clinic were analyzed retrospectively. They were divided into groups according to whether the patients had epidemiological history. The control group was patients without epidemiological history, and the observation group was patients with epidemiological history. Patients were treated in different areas, and all patients were provided with high-quality outpatient management services to optimize the outpatient management mode. The clinical data results, auxiliary examination results, management quality scores, satisfaction cross-infection rate and other indicators were evaluated. Results: the patients in the observation group had lower onset age, shorter waiting time and lower fever patients, which was P<0.05 compared with the clinical data of the control group. The ratio of CT examination, the ratio of viral pneumonia revealed by CT examination, the ratio of nucleic acid detection and the admission rate in the observation group were all at a higher risk level, which was P<0.05 compared with the clinical data of the control group, and no cross infection occurred in the two groups. There was no significant difference in management quality score and satisfaction between the two groups, but the comparison between the two groups was P>0.05. Conclusion: During the epidemic in COVID-19, the fever clinic should constantly adjust its operation mode, improve the professional skills and emergency response ability of medical staff, realize the district management of patients according to their epidemiological history, and then strengthen the prevention and management of changing districts to prevent patients from cross-infection.