The great spirit of combating the covid-19 epidemic is condensed from the inheritance and development of Marxism, the excellent traditional culture of the Chinese nation, and the practice of the Chinese people in fighting the new crown epidemic. It is a great spiritual culture that is consistent with the Chinese revolutionary spirit and socialist core values. Its influence on social customs is reflected in the promotion of truth-seeking style; inspiring the sense of responsibility of contemporary youth's mission; promoting the formation of social customs of solidarity, unity and cohesion, strengthening people's cultural self-confidence and national self-confidence, and perfecting the construction of spiritual civilization. We need to further carry forward The positive influence of the anti-epidemic spirit on social trends, specific suggestions are divided into the integration of anti-epidemic culture into ideological and political education, strengthening the spiritual characteristics of contemporary youth and strengthening the construction of socialist spiritual civilization.