Abstract :In the context of the rising prevalence of chronic diseases in China, chronic disease management and the construction of medical association work together to comprehensively improve chronic disease management capacity on the basis of the linkage mechanism of medical association, guide the graded diagnosis and treatment of common chronic diseases, and speed up the construction of Healthy China. Based on the medical system construction frame of couplet of grading diagnosis and treatment, from the main structure and characteristics of practice, the existing insufficiency of Xiamen, Shanghai, Langfang, Beijing and Foshan summarize five regional slow disease management mode analysis, found that domestic slow disease management in couplet of the internal mechanism of supporting policies, and residents' health consciousness is not enough, It is suggested to improve the chronic disease management mode from the aspects of system and policy, talent team and salary assessment, and promote the high-quality development of chronic disease management on the platform of medical alliance system.