Abstract: Literature analysis and questionnaire survey were used in this study. The questionnaire was filled by the clinical research coordinator clinical trial institution. The purpose was to improve the job satisfaction of CRC, reduce job burnout, reduce turnover, stabilize the clinical trial project team, and find effective countermeasures and reference basis for improving the quality of clinical research. At present, CRC industry is lack of industry identity, some CRC salaries do not match the work intensity, at the same time, CRC itself is lack of clear definition of laws and regulations, division of functional categories, lack of unified and authoritative training and assessment system, which further leads to lack of professional identity, salary and workload mismatch, etc. In order to further improve the quality of CRC work, the administrative departments need to take effective measures to train and manage CRC scientifically and normatively. CRC also needs to improve its own knowledge reserve and working ability to promote the more standardized, more professional and better development of CRC industry in China.