Due to the rapid development of modern communications technology, people are utilizing portable electronic devices more and more frequently in their daily lives, which has led to concerns about whether electromagnetic radiationS(EMF) can be harmful to health. Many studies have demonstrated that exposure to EMF can influence an organism"s or a person"s health. For instance, EMF exposure has been identified as a Group 2B carcinogen and has been associated with a high incidence of numerous disorders. On the other hand, EMF exposure can also be used as a treatment for some diseases, such as radiation therapy and thermomagnetic therapy for cancer. By compiling research findings based on multi-omics big data analysis, this review summarizes the effects of EMF on human health in various omics environments and their biological mechanisms from six aspectsrespectively: cellular bioinformatics, genomics, transcriptomics, proteomics, metabolomics, and microbiomics.These discoveries can assist individuals to reduce the risks of EMF in their daily livesand help us understand the impacts of EMF on human health better.