The paper focuses on the topic of how to enhance medical students' creativity under the background of new medical science, and explores the promotion paths of medical students' creativity through innovation and entrepreneurship education.??Based on the questionnaire data of 1164 undergraduate students, the paper used multiple linear regression analysis and found that theoretical and practical innovation and entrepreneurship education has a significant role in promoting medical students’ creativity, and theoretical education seems to be more important.?In addition, three dimensions of entrepreneurial passion, namely inventing, founding, and developing passion plays an important mediating role, and theoretical innovation and entrepreneurship education has the best effect by stimulating the inventing passion of medical students and then enhancing their creativity.