To explore the effect of emotional exhaustion on satisfaction of decision-making of Attending Physician and the mediating role of work regulatory focus. A total of 300(78%) health care workers from a tertiary public hospital in Chongqing were investigated with the emotional exhaustion scale, the work regulatory focus scale and the decision satisfaction scale. Results descriptive analysis showed that the total score of emotional exhaustion was (21.108 ± 9.135) ,the population suffered of moderate exhaustion and above was 57.94% , the total score of decision satisfaction was (15.712 ± 4.152) ; Correlation analysis showed that emotional exhaustion, promotion focus, prevention focus were correlated with decision satisfaction (r=-0.295、0.402、0.488, P<0.01) ；The mediating effect test showed that emotional exhaustion could affect decision satisfaction indirectly through mediating effect of promoting focus and prevention focus (23.55%,29.42%) . It is necessary to set up a professional emotion processing department, establish a correct cognitive structure of the attending physician responsibility system, and adjust the focus of regulation of different medical personnel.