Based on data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), and 7212 elderly people were selected as the study subjects. SPSS 26.0 was used for descriptive analysis, chi-square test, and binary logistic regression analysis to understand the status quo of loneliness and explore its influencing factors among elderly people with chronic disease in China. The results showed that the incidence of loneliness in our elderly chronically ill population was 26.3%. Males, with a self-rated health average or below, restricted ability to perform daily activities, and more than three types of chronic diseases were risk factors for loneliness in the elderly with chronic diseases(P＜0.05). Primary education level, living with family, having a spouse, affluence, trusting people around, usually having someone to talk to, doing fitness exercises, and community provision of spiritual comfort services were protective factors for loneliness in the elderly chronically ill population(P＜0.05). It should strengthen family support for the elderly with chronic diseases and pay more attention to their mental health. The government should strengthen the construction of community elderly services and facilities and improve the precision of service supply. The elderly should be guided to change their attitude towards life and actively participate in sports activities.