Under the background of major public health events, the mental health of college students is easy to suffer from negative effects, and even psychological crisis. To explore the current situation and family influencing factors of college students' psychological crisis under major public health events is helpful to improve the effectiveness of intervention of college students' psychological crisis. In this study, 879 college students in Jiangsu Province were surveyed through the Internet by convenient sampling method, and SPSS software was used for data analysis. It was found that master's degree (OR=0.245,P<0.05), authoritative family upbringing (OR=1.633,P<0.05), parental restraint, and family relationship with different perceptions (OR=1.854,P<0.05) were significant risk factors for college students' psychological crisis status and cognition of related knowledge. Therefore, under the background of major public health events, we should attach great importance to the influence of family factors on the psychological crisis of college students, and improve the psychological crisis prevention system by actively carrying out psychological survey and interview. Improve and strengthen home-school combined parenting to improve the prevention effect of psychological crisis; To improve the effectiveness of psychological crisis intervention, such as changing the educational concept and creating a good family environment.