It is of great practical significance to integrate the spirit of the 20th National Congress of the Communist Party of China into the construction of the great ideological and political course in medical colleges, which is the need to implement the fundamental task of cultivating morality and cultivating people, the need to explore the reform and innovation of the ideological and political course teaching, and the need to explore the innovation of the teaching mode of the great ideological and political course. However, in the process of specific teaching practice, there are still some shortcomings in the aspects of cooperating with teachers, interpreting teaching content and innovating teaching methods. Therefore, it is necessary to create "great teachers", build " great classroom", build " great platform", integrate into " great culture" and other ways to realize the innovation of the teaching mode of the spirit of 20th National Congress of the Communist Party of China into the ideological and political course of medical colleges.