At present, many controversies on surrogacy, induced abortion and other issues arose across the globe. Teaching bio-ethics on reproduction among international students with diversified backgrounds in China is facing challenges. Due to the different legal and socio-cultural conditions, students often have various understandings about reproductive ethics. From a cross-cultural perspective, this paper analyzes the challenges in teaching process of reproductive ethics, and tries to propose possible ways to innovate teaching methods. This paper proposes methods such as "student-centered" teaching mode, "problem-centered" teaching form and "global and local integration" teaching content to improve the effect of teaching bio-ethics, and provides references for medical humanistic education and ethics teaching practice.