To analyze the changes in healthcare quality evaluation indicators for hospitalized tuberculosis patients under the diagnosis-related group (DRG) payment system, a retrospective analysis was conducted using an interrupted time series regression model. The results showed that after DRG implementation, the total hospitalization costs （β2=-5839.76，P<0.01）, per capita daily hospitalization costs （β3=-34.21，P=0.02）, medication costs （β2=-2866.98，P<0.01）, number of medication varieties （β2=-6.19，P<0.01）, and length of hospital stay（β2=-6.11，P<0.01） significantly decreased. The intervention effect of DRG was particularly notable in drug-resistant tuberculosis patients, with significant improvements in healthcare resource utilization, medical service efficiency, and healthcare quality indicators (P<0.05). The DRG payment model has driven medical institutions to transform their service delivery models and alleviated the financial burden on patients.