Objective: To explore the spatiotemporal evolution patterns of the coupling and coordinated development of medical services, basic medical security, and the pharmaceutical industry in the six central provinces of China, and to predict the changing trends of their coupling coordination degrees from 2025 to 2030, thereby providing references for advancing the orderly development of healthcare under the "Three-Medical Linkage" (integration of medical services, medical insurance, and pharmaceutical reforms) framework.Methods: A coupling coordination degree model was employed to analyze the spatiotemporal evolution of the "Three-Medical" coupling coordination levels in the six central provinces. Based on this, a grey prediction model was applied to dynamically forecast future trends in coupling coordination levels from 2025 to 2030.Results: From 2018 to 2022, the coupling coordination levels of the "Three-Medical" systems in the six central provinces steadily increased, but the overall level remained low with significant regional disparities. Predictions indicate that by 2030, all six provinces will reach coordinated levels, with four provinces entering a high-level coupling stage.Conclusion: The six central provinces should further strengthen primary medical service capabilities, promote reforms in medical insurance payment methods, increase fiscal support, and facilitate the transformation and upgrading of the pharmaceutical industry.