The integration of the spirit of red medicine and the “big ideological and political course” in medical colleges and universities is not only conducive to the implementation of the basic task of building morality and cultivating people, but also it is beneficial to the cultivation of medical ethics of medical students. It is will promote the free and comprehensive development of medical students.It is also will help to stimulate the vitality of the ideological and political course teaching in medical colleges and universities.It is of great significance to the implementation of the healthy China strategy and the promotion of Chinese path to modernization. The integration of the spirit of red medicine with the “big ideological and political courses” in medical colleges has certain shortcomings in terms of ideological recognition, curriculum construction, resource platform integration and talent structure and team. To this end, the integration of the “Red Medicine Spirit” and the “big Ideological and Political Course” in medical colleges can be promoted through improving course content, making good use of social classrooms, integrating resources, building faculty and institutional guarantees, and other paths.