In order to comply with the internationalization trend of medical education, and establish student training criteria and complete supporting facilities with the purpose of guaranteeing and improving the quality of medical education in China, the article made a comparison on cultivating objectives and target student selection of eight-year-system medical education between the US and China. Through analysis of advantages and disadvantages, the authors provided some advices on reform and development of eight-year-system medical education from perspectives of conception change, target student selection, identification and further detail of cultivating objectives and etc.