Objective: To investigate the mode of blood purification inservice training for specialized nurses,and cultivate clinical nursing specialist in blood purification. Methods: For the qualifications of trainee and training objectives,training bases designed curricula specially combining the reported experience home and abroad and expert’s argumentation,and trained 25 participants enrolled in 2008,2009 according to the curriculum. Results: 22 of 25 trainees well assessed by the experts evaluation with passing rate of 88%. Conclusion: Through the training,our hospital blood purification centre has achieved good results and futher accumulated the experience of training for specialist nurses.