Asymmetric information and mistrust between doctor and patient are the main reason of medical disputes. Using the doctor-patient communication to transfer the doctor-patient knowledge is the main approach to solving this problem. The doctor-patient interaction is a typical two-way communication, which plays a very important role in the doctor-patient knowledge transfer. Our research designed the doctor-patient interaction questionnaire on the basis of review of literature, interviews and pre-research questionnaire, and then took the empirical investigation in Zhejiang province. The authors classified the patients by means of a cluster analysis into four groups with the situation of interactions. In view of behavioral characteristics of the patients,different doctor-patient interaction strategies were suggested in order to perform effective doctor-patient communication and interaction.