In this article 1 017 college students were investigated with PIL and SIOSS. Results showed that only 22.9% had definite life purpose and 6.0% had suicidal intension. Additionally, college students’ life-meaning feeling had significantly negative correlation with suicidal intension. Multiple regression analysis showed that college students’ life value, life attitude and life independence could predict their suicidal intension, of which life value gave the best prediction. Therefore, college students’ suicidal intension could be predicted by their life-meaning purpose, and suicide could be prevented in advance.