Objective:To study the application of the electronic health information record in chronic disease management mode. Methods:Management conditions of three kinds of chronic disease that was hypertension,diabetes mellitus and malignant tumor in Gulou district of Nanjing city from October 2008 to October 2011 were studied,which were divided into three periods as Period A from October 2008 to September 2009,Period B from October 2009 to September 2010 and Period C from October 2010 to September 2011. The area number,filing management number,filing management rate,standardized management number and specification management rate at the three periods were investigated. Results:By the end of September 2011,598 800 regulative electronic health records had been completed with filing rate 72.43%,among which 333 400 were standard managed with standardized management rate 55.68%. Period C and Period B were significantly higher than Period A(P < 0.05),Period C in filing management number and filing menagement rate were statistically higher than Period B(P < 0.05),and the difference between Period B and Period C in standardized management number and specification management rate were statistically meaningless(P > 0.05). Conclusion:Chronic disease information management mode can effectively integrate medical resources and realize the scientific management of chronic diseases’ prevention and control. It can realize the dynamic observation of individuals and groups of related health problems,regularly evaluate,timely find problems and respond to intervene and control,and effectively improve the chronic disease management.