Objective:To compare disease characteristics,quality of life and economic burden between patients with psoriasis and eczema. Methods:Total 198 patients with psoriasis and 117 patients of eczema were selected for questionnaire survey using SF-36 scale and Skindex-29 scale in Dermatology Hospital of the Chinese Academy of Medical Sciences from June 2011 to March 2012. Results:①A total of 313 questionnaires were valid,of which 196 cases were psoriasis with the male to female ratio is 1.88∶1,and 117 cases in the control group with male to female ratio is 1.25∶1. Psoriasis was compared with eczema in terms of the social behavior,such as smoking,drinking,sleeping,diet limitation,suicide tendency,et al. And we found that psoriasis had a higher percentage than eczema in smoking,sleeping,and suicidal tendency (P < 0.01).②Comparing the quality of life between patients with psoriasis and eczema by SF-36 and Skindex-29 scales,we found that patients with psoriasis had a lower quality of life than patients with eczema (P < 0.01).③The economic burden of psoriasis is more serious than that of the control group. Conclusion:The results of psoriasis and eczema were generally similar to the previous studies. However,psoriasis had a significantly higher proportion of smoking,drinking,suicidal tendencies. Although psoriasis and eczema were both skin diseases,the psoriasis had a much lower quality of life than the eczema,health workers should pay much attention to the quality of life of patients with psoriasis when in diagnosis and treatment. The economic burden of psoriasis was more severe than that of eczema. Therefore,health policy-making department should pay much more attention to psoriasis with severe economic burden.