Objective:To study the mode of problem-based learning combining with scenario-based medical cases in cardiology learning. Methods:160 interns were randomly divided into experimental and control groups. Experimental group were given by problem-based learning combining with scenario-based medical cases mode,and control group were given question-case discussion mode. An examination was then carried out to evaluate their achievement. Results:Students of experimental group achieved higher scores at choice questions,subjective topic,case analysis and even their total scores (P < 0.05). They believed that the new teaching mode could do better work at focus interest,raising enthusiasm and promoting their skills of communication and collaboration. More participants preferred problem-based learning combining with scenario-based medical cases mode (P < 0.05). Conclusion:Problem-based learning combining with scenario-based medical cases mode played better effect on rising interns not only clinical thinking,but also analysis and solving skills of cardiology.