Objective:To evaluate the effect of group counseling intervention on career decision-making self-efficacy of nursing students. Methods:48 junior nursing students in vocational colleges were randomly divided into experimental group and control group. Experimental group were received 8 weeks group counseling. Two groups of students were investigated with the career decision making self-efficacy scale(CDMSES)and coping style questionnaire (CSQ)before and after group counseling. Results:After the group counseling,the CDMSES score and mature coping style score in the experimental group were significantly higher than those in the control group(P < 0.05); immature coping style score was significantly lower than that of control group(P < 0.01). Conclusion:Group counseling intervention can effectively improve nursing students’ career decision-making self-efficacy,and enhance their ability to cope with difficulties.