Objective: To explore the mediating effect of coping style on perfectionism and employment anxiety among medical undergraduate students, and to provide evidence for alleviating their employment anxiety. Methods: A total of 220 undergraduate students were selected and demanded to complete the Frost multidimensional perfectionism scale, coping style questionnaire and employment anxiety questionnaire. Results: The results showed the following:(1)the female undergraduate students showed more employment uneasy than the male students, and the medical students showed more job anxiety than the non-medical students.(2)There were significantly positive correlations among maladaptive perfectionism, negative coping style and employment anxiety.(3)Negative coping style partially mediated the relationship between maladaptive perfectionism and employment anxiety. Maladaptive perfectionism and negative coping style played important roles in undergraduate students’ employment anxiety, and the mediating effect covered 13.2% of the total effect. Conclusion: We should avoid the negative influences of the maladaptive perfectionism and reduce the frequency of negative coping style to ease the employment anxiety of undergraduates.