To compare and analyze the prevention and treatment knowledge and compliance of patients with hypertension from different rural areas of Jiangsu Province, study the influencing factors, so as to provide reference bases for exploring “country-township-village” cooperative hypertension management strategy. Methods: Descriptive analyses such as adoption rate were applied to analyze awareness of knowledge and compliance. Inferential analyses such as Chi-square test and logistic regression were applied to analyze the influencing factors. Results: The awareness rate of knowledge was 75.6% (southern 64.8%, middle 74.6%, and northern 84%), and marital status, educational level and different areas were its influencing factors. A total of 88.2% of hypertension patients’ compliance of medicine intake were better (southern 92.9%, middle 92.6%, northern 79%), and different areas and awareness of knowledge were its influencing factors. Conclusion: Different areas should be combined with their own characteristics to build a “country-township-village”hypertension longitudinal cooperation team, and improve patients’ knowledge and compliance.