Objective: To analyze the hospitalization expenses and its influencing factors of chronic patients and provide the basis for controlling the hospitalization expenses. Methods: We collected the medical data of hospitalized chronic patients from a general hospital in Anhui Province in 2014, SPSS 18.0 was used to describe the hospitalization expenses and analyze the influencing factors. Results: The average hospitalization expenses, drug expenses, inspection expenses and laboratory expenses of chronic patients were 8 207.5 yuan, 3 442.5 yuan, 1 275.0 yuan and 1 057.5 yuan, respectively. For hypertension, diabetes and intervertebral disk disease, the average hospitalization expenses were 5 929.2 yuan, 10 384.1 yuan and 8 900.2 yuan, respectively; the proportion of drug expenses to hospitalization expenses were 33.9%, 47.4% and 34.9%, respectively. There was a positive correlation between hospitalization days and hospitalization expenses. Age, hospitalization days and type of disease were factors of hospitalization expenses. Conclusion: The hospitalization expense of chronic patients was high and the economic burden was heavy. The hospitalization expenses and proportion of drug expenses of diabetics were the highest. The hospitalization duration of intervertebral disk disease patients was the longest. The elderly were high risk groups for chronic diseases.