Objective: To investigate the relationships between employment pressure, career adaptability and suicidal ideation among college students. Methods: The random sampling was performed to select 360 junior and senior students from five schools of Henan and Fujian. The university graduate employment pressures questionnaire, college students’ career adaptability questionnaire (CSCAQ) and self-rating idea of suicide scale (SIOSS) were used for investigation. Results: Significant gender differences were found in employment pressure and suicidal ideation (P＜0.05). The employment pressure of senior students was significantly higher than that of junior students (P＜0.05). The results showed that the employment pressure of college students was positively related to suicidal ideation (r=0.398，P＜0.001), and negatively related to career adaptability (r=-0.180，P＜0.01); and career adaptability and suicidal ideation were negatively correlated (r=-0.431，P＜0.001). Multiple regression analysis showed that career adaptability played a mediate role between employment pressure and suicidal ideation (P＜0.001). Conclusion: College students’ employment pressure was significant differences in grade and sex variables, and influenced suicidal ideation significantly. Improving the career adaptability of college graduates’ can effectively reduce the suicidal ideation caused by employment pressure.