Objective： To investigate the relationship between positive psychological capital and learning burnout among medical university students. Methods： A total of 650 medical university students were tested using positive psychological capital questionnaire and learning burnout questionnaire. Results： About 34.9%（216） of medical university students felt the learning burnout. Positive psychological capital was negatively related to learning burnout（P<0.01）. Multiple regression analysis indicated that hope factor and resilience factor were the effective predictors of learning burnout. Conclusion： It is important to strengthen the positive psychological capital and prevent burnout of medical university student.