Based on introducing the reform of performance management in Wuxi No. 2 People’s Hospital, this paper analyzes the reform measures and methods of performance management based on the strategic scorecard, and analyzes the effect of improving the learning and innovation ability of hospital staff. The results show that the quality of research papers is improved, the effectiveness of continuing education of new employee is remarkable, the breakthrough of scientific research is achieved, and the number of authorized patents is greatly improved. It is very important for the hospital to set up the target development strategy. The development of staff's innovative ability determines the realization of the development strategy of the hospital, and the idea of performance management is the essence of the strategic scorecard. This study can provide reference for similar hospitals to strengthen scientific research and learning innovation ability through performance system reform and promote the sustainable development of hospitals.