Convenience sampling method was used to select 218 patients from the outpatient department of dermatology in a provincial public hospital in Nanjing from June 2017 to September 2017. Doctor?patient interaction recording, questionnaires, logistic regression and One?way ANOVA were used to find out factors influencing patient satisfaction during doctor?patient interaction. Satisfaction in the outpatient department of dermatology was not significantly correlated with the demographic characteristics, but with doctors’ linguistic manners, disease interpretation and guidance of drug use. Dermatologists change the language habit, pay attention to the linguistic manners, disease interpretation and guidance of drug use can improve the patient’s satisfaction.