Chinese medicinal materials are popular with Chinese customers and have broad market prospects. To provide consumers with safe Chinese medicinal materials is an indispensable issue in drug regulation. However, the dual nature and the vagueness of the definition on Chinese medicinal materials make it difficult for the drug supervisory and administrative departments to determine the Chinese medicinal materials accurately to influence the regulatory efficiency. This article is based on the status quo of online drug regulation and analyzes how to implement effective supervision in terms of essential properties of Chinese medicinal materials, in order to offer some beneficial suggestions on drug supervision.