Craftsman Spirit was highly praised in ancient Chinese manufacturing, education and other industries, and it was also the continuing motivation of the inheritance of academic fumes of traditional Chinese medicine for thousands of years. Its connotation is embodied in the following aspects: “working for the cure of illness and not treating illness” and “great doctors are sincere”. However, due to the influence of Western learning and impetuous social psychology, the spirit began to decline to a certain extent. In the new era, inheriting and innovating traditional Chinese medicine must be guided by value rationalism, and further cultivate and promote Chinese medicine craftsman spirit in the background of the integration of Chinese and Western medicine and international cooperation and exchange.