In order to explore the incidence and the credibility of the differences of statutory legal infectious diseases in Zhejiang and Shanghai， the feasibility of evaluating the effect of work from the perspective of researchers and the importance of accurately evaluating the effect of work were examined. Collect relevant literature on the effects of prevention and control of infectious diseases， extract the expressions about the work effects， and assign them with the “five?point scale method”. Spearman correlation and linear regression were used to analyze the relationship between the appropriate degree of work effect and the incidence of legal infectious diseases. The results showed that the appropriate degree of prevention and control of infectious diseases in Zhejiang and Shanghai showed an upward trend. Shanghai increased from 51.8% in 2000 to 64.7% in 2017， and Zhejiang increased from 34.4% to 57.5%. Moreover， the appropriate degree of work effect between Zhejiang and Shanghai was negatively correlated with the incidence of legal infectious diseases， and the correlation coefficients were -0.691 and -0.625， respectively. The results suggested that the effect of prevention and control of infectious diseases in Zhejiang and Shanghai had been improved， but it still needs to be improved； the improvement of the appropriateness of work effect in Zhejiang and Shanghai had an important impact on improving health outcomes； quantitative evaluation of the effectiveness of infectious disease prevention and control based on the perspective of researchers was feasible.