Literatures and information reports on the utilization of infectious disease information published in Zhejiang and Shanghai were collected systematically， and the effective utilization degree was calculated quantitatively. Spearman correlation and linear regression were used to analyze the relationship between the effective utilization of infectious disease information and the incidence of class a and b infectious diseases. Results showed the effective use of information on infectious diseases in Zhejiang increased from 0.3% in 2000 to 9.8% in 2017， and from 2.9% in 2000 to 17.5% in Shanghai. There was a significant negative correlation between the timeliness of Zhejiang and Shanghai and the incidence of class a and b infectious diseases （P<0.01）， with 47.2% and 79.2% explaining the incidence of infectious diseases respectively. The effective use of information of infectious diseases in Zhejiang and Shanghai is different， but the use of information in Zhejiang was low. It showed that the effective use of disease monitoring information was the premise for the prevention and control of infectious diseases； the two places still need to strengthen the effective use of infectious disease information； the method used to quantify the effective use of infectious disease information in a country （or region） is scientific and feasible， which can be applied to other public health fields or regions.