Using statistical analysis, the change trend of standard scores of medical waste disposal in six districts of Nanjing was investigated, and the differences between different years and districts were compared. It was showed that the differences from 2016 to 2017 and from 2017 to 2018 in the standard scores of medical waste disposal in primary medical institutions in the six districts of Nanjing were statistically significant (P<0.05). The overall capacity of medical waste disposal in primary medical institutions in Nanjing had been improved significantly year by year. In particular, Gaochun district did the best in the medical waste disposal among the six districts. Among the survey items on the medical waste disposal,“using special packaging and containers” had been improved the most, “disinfection treatment and monitoring of hospital sewage” still needed to be strengthened in the future.