To analyze the characteristics and influencing factors of inpatient expenses of COVID?19 patients， we collected 118 patients with COVID?19 who were discharged from the Huangshi Traditional Chinese Medicine Hospital in Hubei Province from February 5 to March 25，2020. The descriptive analysis， stepwise regression analysis， and grey relational analysis were used. Univariate analysis showed that age， disease severity， underlying diseases， complications， and use of hormones， immunomodulators， blood products， antibiotics， and ventilators had impact on inpatient expenses. The proportion of western medicines was the highest in the inpatient expenses. The regression equation had good goodness of fit. The inpatient expenses were affected by using ventilators， immunomodulators， and blood products.