This paper analyzed the satisfaction evaluation of the patients in 25 hospitals in Jiangsu Province on the comprehensive reform of public hospitals. The results showed that patients were generally satisfied with the evaluation of the comprehensive reform effect of public hospitals. The satisfaction of four dimensions of medical insurance and price， medical services， the tiered system of diagnosis and treatment， and the medical environment all had impact on the overall satisfaction， F=463.211， P<0.001. Among them， the satisfaction of two dimensions， i.e. medical insurance and price， together with medical services， had the greatest impact on the overall satisfaction of patients， and the standardized regression coefficients were 0.406 and 0.298， respectively. At the same time， patient satisfaction in northern Jiangsu was the lowest in all regions of the province， with a score of 4.78. It is recommended to enhance the comprehensive reform of public hospitals in terms of medical insurance， prices， and medical services， and at the same time improve the status quo of medical reform in northern Jiangsu， which will be conducive to the further deepening of comprehensive medical reform within Jiangsu Province and the overall improvement of patient satisfaction.