To explore the optimization of the fever clinic management mode in COVID?19 epidemic period and its effect in Kezhou Peoples Hospital. 1 950 patients who visited the fever clinic between January to March 2020， were divided into the control group and the observation group according to whether they had epidemiological history. Patients were treated in different zones， and all patients were provided with high?quality outpatient management services to optimize the outpatient management mode. Results showed that in the observation group patients had lower onset age and shorter waiting time； the number of patients with fever was smaller； the ratio of CT examination， viral pneumonia revealed by CT examination， and nucleic acid detection was higher； and the admission rate was also higher. The differences in the value of those previously mentioned indicators between the observation and control group were all of statistical significance（P<0.05）. No cross infection occurred in the two groups. There was no significant difference in the management quality score and satisfaction between the two groups. During the COVID?19 epidemic period， the fever clinic should constantly adjust its operation mode， improve professional skills and emergency response ability of medical staff， conduct zoning management of patients according to their epidemiological history， and then strengthen the zoning prevention management of patients to prevent cross infection.