This study discussed the risk prevention and control strategies of large hospitals for rainstorm and flood disasters， used brainstorming and disaster vulnerability analysis to identify the main risk events faced by large hospitals， and formulated and published the hospital building disaster vulnerability assessment form under rainstorm and flood in combination with the actual operation and management of the hospital， so as to analyze the event risk value and matrix distribution. The evaluation results showed that the high?risk events with the possibility were greater than 0.5 and the risk value ranking in the top 5 needed more attention， namely medical power failure（30.65%）， water flowing?back buildings（30.03%）， equipment trouble（28.73%）， patients’ transport difficulties（28.42%）， insufficient oxygen supply（27.95%）. On the basis of assessment results of disaster risk， for high?risk value events， the organization department shall construct corresponding risk prevention and control strategies from two aspects of pre?disaster prevention and in?disaster response. While for other low?risk value events， the management department shall take the lead and formulate corresponding preventive measures according to the severity of the disaster.