Objective: To explore communication skills between doctors and patients who undergoing transurethral resection of the prostate (TURP) in perioperative period, to reduce the doctor-patient contradiction resulted from early complication after TURP, and to improve satisfaction of the patients. Methods: A total of 210 patients who undergoing TURP were enrolled in this prospective study. Participants were randomly divided into 2 groups. As the study group, group 1 patients received a novel scientific communication method by the application of enhanced Calgary-Cambridge Guide extended communication frame, doctor-patient communication decision tree model based on Parto principle, and doctor-nurse-patient tripartite communication. As the control group, group 2 patients received a traditional communication. Complication and satisfaction of all patients were observed and compared between 2 groups by follow-up. Results: No significant differences in the incidence rate of complication of 2 groups patients were found by Chi-square test (P=0.895). However, there was a significant difference in the occurrence rate of doctor-patient contradiction between 2 groups (P=0.015), and satisfaction of patients in the study group was superior than those in control group (P < 0.001). Conclusion: Scientific, timely and effective communication between doctors and patients could reduce the contradiction resulted from early complication after TURP and improve satisfaction of patients.