Objective：This study aimed to investigate the occupational burnout of psychiatric medical staff in Inner Mongolia and its relationship with social support. Methods: A total of 360 psychiatric medical staff were sampled in mental hospitals and general hospitals of Inner Mongolia and were investigated by Perceived Social Support Scale (PSSS) and Maslach Burnout Inventory-Human Service Survey (MBI-HSS) and then the results were analyzed. Results: The average scores of each dimension of mental health worker’s occupational burnout in Inner Mongolia was that: emotional exhaustion (3.40±1.41) points, depersonalization(2.52±1.70) points, sense of personal achievement (3.84±1.43) points; There was a significant different in social support between the staff with different sex, marital status, education level, working years and management positions; Significant negative correlation also existed among social support and negative emotions in occupational burnout, including emotion exhaustion and depersonalization. Significant positive correlation existed among social support and personal accomplishment. The recession analysis showed that sex, formation, management positions, working years, and social support play a significant role in prediction of emotional exhaustion; Social support, sex, management positions, positional titles, and age play a significant role in the prediction of depersonalization; Social support, management positions, positional title, and age play a significant role in the prediction of sense of personal achievement. Conclusion: We should pay attention to the problem of occupational burnout of psychiatric medical staff and fully consider the influence of social support to occupational burnout.