温度/超声双重响应型相变液滴对水凝胶结构性能的调控
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(Correspondingauthor),E?mail:duanlei@njmu.edu.cn

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R318.5

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国家重点研发计划(2019YFA0210104);国家自然科学基金(81701833);江苏省重点大学生创新创业训练计划项目(KY124J2019065)


Structure and properties regulation of hydrogels by temperature/ultrasound dual⁃responsive phase⁃change droplets
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    摘要:

    目的:制备温度/超声双重响应型脂质相变液滴(lipid phase?change droplet,LPCD),并将其与水凝胶进行复合,通过温度或低强度聚焦超声(low intensity focused ultrasound,LIFU)调控LPCD的内核发生液?气相转变,继而调控水凝胶的结构和力学性能。方法:首先通过薄膜水化法制备出脂质膜壳的全氟己烷(perfluorohexane,PFH)相变液滴,对其在温度和LIFU调控下的形貌变化、相转变能力进行表征,同时评估液?气相变前后LPCD的超声造影能力。在此基础上将其与水凝胶进行复合,通过各项表征评估温度/超声引起的液滴相变对水凝胶内部结构、浮力和机械性能的影响。结果:LPCD在温度或超声调控下有良好的相转变能力和超声造影能力。脂质液滴相变可使水凝胶内部生成直径在微米量级的诸多气孔,浮力得到显著提高, 压缩应力和溶胀性能也有所变化。结论:脂质相变液滴?水凝胶复合材料(LPCD@Hy)是一种有潜力的智能响应型诊疗用微纳材料。

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    Objective:Prepare temperature/ultrasound dual?responsive lipid phase?change droplet(LPCD)and combine them with hydrogels to regulate liquid?gas transitions in the core of lipid droplets by temperature or low intensity focused ultrasound(LIFU),and then regulate the structure and mechanical properties of the hydrogels. Methods:Firstly,perfluorohexane(PFH)phase ? change droplets of lipid membrane shell were prepared by thin?film hydration method. The morphological changes and phase transition ability under the control of temperature and LIFU were characterized. At the same time,the contrast ?enhanced ability of LPCD before and after liquid?gas phase transition was evaluated. On this basis,it was combined with hydrogels,and the effects of temperature/ultrasound induced droplet transition on the internal structure,buoyancy and mechanical properties of hydrogels were evaluated by characterization. Results:LPCD had good phase transition ability and contrast ? enhanced ultrasound ability under the control of temperature or ultrasound. Lipid droplet phase transitions caused many micropores inside the hydrogel,which significantly improved buoyancy,varying compressive stress and swelling properties. Conclusion:Lipid phase?change droplets?hydrogel composite material (LPCD@Hy)is a kind of potential intelligent response micro/nano material for diagnosis and treatment.

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赵婵,刘昊,陈洁莹,徐雪琴,胡克,段磊.温度/超声双重响应型相变液滴对水凝胶结构性能的调控[J].南京医科大学学报,2022,(7):948~956

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  • 在线发布日期: 2022-07-15
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