Objective：Prepare temperature/ultrasound dual⁃responsive lipid phasE-change droplet(LPCD)and combine them with hydrogels to regulate liquid⁃gas transitions in the core of lipid droplets by temperature or low intensity focused ultrasound(LIFU)，and then regulate the structure and mechanical properties of the hydrogels. Methods：Firstly，perfluorohexane(PFH)phase ⁃ change droplets of lipid membrane shell were prepared by thin⁃film hydration method. The morphological changes and phase transition ability under the control of temperature and LIFU were characterized. At the same time，the contrast ⁃enhanced ability of LPCD before and after liquid⁃gas phase transition was evaluated. On this basis，it was combined with hydrogels，and the effects of temperature/ultrasound induced droplet transition on the internal structure，buoyancy and mechanical properties of hydrogels were evaluated by characterization. Results：LPCD had good phase transition ability and contrast ⁃ enhanced ultrasound ability under the control of temperature or ultrasound. Lipid droplet phase transitions caused many micropores inside the hydrogel，which significantly improved buoyancy，varying compressive stress and swelling properties. Conclusion：Lipid phasE-change droplets⁃hydrogel composite material (LPCD@Hy)is a kind of potential intelligent response micro/nano material for diagnosis and treatment.