母体微生物群对妊娠并发症及子代发育的影响
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(Correspondingauthor),E?mail:diaofeiyang@njmu.edu.cn

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R714.25

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国家重点研发计划(2016YFC1000200,2018YFC1003800)


The effect of maternal microbiota on pregnancy complication and offspring development
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    摘要:

    人体微生物群与宿主构成了相互制约、相互协调的微生态平衡,对人类健康而言不可或缺。各种原因导致的微生态失衡可能是人体多种疾病的重要致病因素。近年来,对女性生殖道、肠道微生物群与疾病的研究取得了突破性进展,提示其对妊娠期糖尿病、早产及先兆子痫等妊娠并发症的发生、发展和预后可能起重要作用。此外,母体生殖道、乳汁和肠道等部位的微生物群还可能影响新生儿代谢、免疫系统和神经系统的发育和功能。本文选择女性生殖道和肠道微生物群对妊娠并发症及子代发育影响的相关研究进行综述,以期为相关研究提供新视角、新思路。

    Abstract:

    Objective:The human microbiota and the host constitute a mutually restricted and coordinated microecological balance, which is indispensable for human health. Microecological imbalance caused by various reasons may be an important pathogenic factor of many diseases in human body. In recent years,the research on female reproductive tract microbial community,intestinal flora and diseases has made a breakthrough,suggesting that they may play an important role in the occurrence,development and prognosis of obstetrics complications including preterm birth and gestational diabetes mellitus. In addition,it’s undeniable that the microbiota of the maternal reproductive tract,breast milk and intestinal tract may also influence the development and function of the neonate metabolism,immune system and nervous system. Here we review the studies on the impact of female reproductive tract flora and intestinal microbiota on pregnancy and offspring,in order to provide a new perspective and new ideas for future research.

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徐影,刁飞扬.母体微生物群对妊娠并发症及子代发育的影响[J].南京医科大学学报,2022,(7):1030~1035

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  • 在线发布日期: 2022-07-15
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